• Revolutionizing Medicine: Breakthrough Cell-Based Delivery System for Targeted Therapy Unveiled.

    Author(s):
    Rojopitiavana Solofondrazaintsoanirina (see profile)
    Date:
    2023
    Subject(s):
    Cells, Therapeutics, Drug delivery systems, Cancer
    Item Type:
    Article
    Tag(s):
    Cancer, cell-mediated delivery, chemotherapy, nucleic acids, therapeutic
    Permanent URL:
    https://doi.org/10.17613/fey6-8980
    Abstract:
    The global burden of cancer remains high, with tens of millions of new cases being diagnosed and millions of lives being lost to the disease each year. Chemotherapy and targeted therapies have limitations and can cause serious side effects. Nucleic acids, including DNA and RNA, offer immense potential as innovative therapeutics for the treatment of cancer and various diseases, but their delivery to the target cells of tissues is very challenging. Various carriers have been developed to enhance delivery, including lipid nanoparticles and viral vectors, but challenges such as immunogenicity and off-target accumulation remain. Cell-mediated delivery systems offer important benefits, including a longer circulation time, enhanced homing to the target site, improved biocompatibility, and the possibility of engineering the cell carriers to sense and respond to disease-associated biomarkers. This paper provides an overview of currently disclosed cell-based delivery systems and proposes improvements to address their limitations. A versatile delivery system that could revolutionize medicine by achieving targeted delivery of therapeutic nucleic acids to specific tissues while minimizing side effects is presented.
    Metadata:
    xml
    Status:
    Published
    Last Updated:
    6 months ago
    License:
    Attribution-NoDerivatives
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