• Computational Analysis of Organic Anion Transport Proteins

    Author(s):
    James VanAntwerp (see profile)
    Date:
    2020
    Item Type:
    Presentation
    Meeting Title:
    Mid-SURE
    Meeting Org.:
    Michigan State University
    Meeting Loc.:
    Online
    Meeting Date:
    August 4-10 2020
    Tag(s):
    biological information
    Permanent URL:
    http://dx.doi.org/10.17613/xwtk-r252
    Abstract:
    This project will use ancestral sequence reconstruction and computational modeling to inform the design of novel function in human OATP proteins with the dual goal of enhanced uptake of MRI contrast agents and non-immunogenic properties. These new functions will allow cells introduced into the body, such as stem cells or immunotherapies to be accurately tracked. This design will also lend insight into the sequence-structure-function connections in OATPs, which is invaluable for a number of therapies. In this study, to discover specific domains or positions that confer activity, we will compare ancestral sequences with a selection of extant sequences to discover the evolutionary changes within the family. That evolutionary data will inform mutational information such that any OATP could be given intentional, designed mutations for any desired functionality.
    Metadata:
    Status:
    Published
    Last Updated:
    2 years ago
    License:
    Attribution-NonCommercial-ShareAlike
    Share this:

    Downloads

    Item Name: pdf ensure-poster.pdf
      Download View in browser
    Activity: Downloads: 35